GLP-1 for Weight Loss: What Every Patient Should Know
GLP-1 medications are changing the conversation around weight management — and as a dietitian, I see both the incredible potential and the hidden pitfalls. Whether you’ve heard of Ozempic, Wegovy, or Zepbound, or you’re just starting to explore options, this guide will help you understand what GLP-1s are, how they work, and why nutrition support is key to long-term success.
What Is GLP-1 and How Does It Work?
GLP-1 stands for glucagon-like peptide-1, a hormone your gut naturally produces after you eat. It signals your brain that you’re full, slows down digestion, and helps regulate blood sugar.
GLP-1 medications (like semaglutide and tirzepatide) mimic this natural hormone — leading to:
Reduced appetite
Lower blood sugar spikes
Clinically significant weight loss
GLP-1 Benefits Beyond Weight Loss
Although weight loss is the main reason people start these medications, research shows GLP-1 therapies may also:
Improve heart health by lowering cardiovascular risk
Support liver health in conditions like fatty liver (MASH/NAFLD)
Reduce sleep apnea severity
Lower cravings for alcohol or certain foods
This is why some doctors see GLP-1s as more than a weight-loss tool — they can be a total health reset.
What Real-World Results Look Like
Clinical trials often show double-digit percentage weight loss, but in everyday life, the numbers can be a little lower. Current data suggests:
Average weight loss with semaglutide: ~7–8% of body weight
Average weight loss with tirzepatide: ~12% of body weight
Adherence is improving: over 60% of patients stay on therapy after 12 months (a big jump from 2023!)
The Dietitian’s Role: Why Nutrition Support Matters
This is where I come in. While GLP-1s help reduce appetite, they also reduce overall food intake — sometimes too much. Without guidance, this can lead to:
Muscle loss
Nutrient deficiencies
Digestive side effects like nausea or constipation
As a dietitian, I help my clients:
Choose high-protein meals to preserve muscle
Get enough fiber to support gut health
Avoid overly restrictive eating that leads to rebound weight gain
Learn strategies to eventually transition off the medication if appropriate
The Truth About “GLP-1-Friendly” Foods
You may have seen products marketed as GLP-1-friendly — but there’s no regulation for that label. Instead of chasing marketing trends, focus on:
Lean protein at every meal
Vegetables, fruits, and whole grains for fiber
Hydration (GLP-1s can reduce thirst cues)
Mindful eating practices
Practical Tips for Success on GLP-1
Don’t skip meals — focus on balanced plates, even if portions are smaller.
Prioritize protein — aim for 20–30g per meal.
Hydrate — keep water nearby, especially if nausea makes you drink less.
Move your body — strength training is key to protecting muscle mass.
Work with a professional — a GLP-1-informed dietitian can help you customize your plan.
Final Thoughts: Medication + Nutrition = Best Results
GLP-1 medications are powerful tools — but they work best when paired with a nutrition plan tailored to your body, preferences, and goals. If you’re considering GLP-1 therapy or are already taking it, I can help you maximize results while staying healthy and strong.
📅 Ready to start? Book a consultation and let’s create a plan that works with your medication, not against it.